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New Study Identifies Promising Treatment Target for Traumatic Brain Injury – ET HealthWorld



Study reveals novel therapeutic target for traumatic brain injury, ET HealthWorld

In a recent study published in the Journal of Neuroinflammation, scientists at Gladstone Institutes have made a breakthrough discovery regarding the mechanisms behind traumatic brain injuries. The research reveals that a specific blood protein, fibrin, plays a pivotal role in causing brain damage after injury, triggering neurodegeneration and toxic immune responses.

Traumatic brain injuries, which affect approximately 1.5 million Americans each year, can result from various incidents such as falls, car crashes, assaults, sports accidents, and military operations. These injuries disrupt the blood-brain barrier, allowing blood to leak into the brain and leading to harmful effects on neurons.

Led by Jae Kyu Ryu, PhD, and Katerina Akassoglou, PhD, the study utilized advanced imaging technology to analyze mouse brains and brains from individuals who experienced traumatic brain injuries. The researchers found that fibrin activates immune cells, sparking dangerous inflammation and releasing toxins that harm neurons.

The team developed a genetic tool with a specific mutation in fibrin that blocks its inflammatory properties without affecting its blood-clotting abilities. This targeted approach could potentially mitigate the devastating effects of brain injuries, offering a new therapeutic strategy for neurological diseases.

Akassoglou’s lab has already developed a fibrin-targeting immunotherapy that has shown promising results in protecting against multiple sclerosis and Alzheimer’s disease in mice. A humanized version of this immunotherapy is currently undergoing Phase 1 safety clinical trials by Therini Bio.

This groundbreaking research paves the way for future studies to explore the efficacy of fibrin immunotherapy in treating traumatic brain injuries and improving patient outcomes. By understanding the role of fibrin in neurodegeneration, scientists aim to develop innovative therapies that can mitigate the long-term consequences of brain injuries and enhance overall neurological health.

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