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How specific lipids indicate tissue ageing, and how exercise decreases them: Study in ET HealthWorld

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Study reveals how specific lipids indicate tissue ageing, decreases through exercise, ET HealthWorld

In a groundbreaking discovery by researchers from Amsterdam UMC and Maastricht UMC+, it has been found that a form of fat builds up as tissue ages and can be reversed through exercise. The findings, published in the journal Nature Ageing, shed new light on the aging process and potential interventions.

Professor Riekelt Houtkooper from Amsterdam UMC emphasized the significance of the study, stating, “The idea that we could reverse aging is something that was long considered science fiction, but these findings allow us to understand more about the aging process.” The research team, led by assistant professor Georges Janssens, conducted experiments on rats and human tissue before and after exercise to arrive at their conclusions.

The study focused on the accumulation of a specific type of lipid, bis(monoacylglycero)phosphates (BMPs), in various tissues of older animals and humans. The researchers noted elevated levels of BMPs in older tissue samples, suggesting a correlation with aging. Furthermore, muscle biopsies from older individuals showed a similar increase in BMP levels, which decreased after regular exercise.

Houtkooper emphasized that while the results mark a significant advancement in understanding aging, further studies are needed to explore the role of BMPs in aging and whether exercise is the only way to affect BMP levels. The findings open up new possibilities for interventions in age-related diseases and pave the way for future research in the field of aging and metabolism.

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